DECOLL

Collagen Dura Membrane for Neurosurgical Applications

In modern neurosurgery, the protection and reconstruction of the dura mater is essential in maintaining central nervous system integrity, especially during or after invasive procedures such as tumor excision, spinal decompression, or trauma repair. Designed to serve as a biologically compatible dural substitute, DECOLL offers a clinically advanced solution for neurosurgeons seeking both performance and safety in dural closure.

DECOLL is a single-use, collagen-based dura membrane derived from ultra-pure type I bovine collagen. Containing over 95.5% type I collagen, it closely mimics the composition of native dura tissue, offering a familiar biological interface for cellular integration, rapid healing, and reliable CSF barrier function. It is sterilized using gamma radiation and delivered ready to use, requiring no pre-treatment or preparation before application.

CE-Certified and ISO-Compliant

Desu is proud to deliver DECOLL with full CE certification, ensuring that it meets the rigorous health, safety, and environmental protection standards required for use in European and international healthcare settings. In addition, our manufacturing processes conform to ISO 13485 standards for medical devices, which guarantees consistent quality, traceability, and full regulatory compliance throughout the product lifecycle.

DECOLL is also supported by a comprehensive technical file and quality assurance documentation, available upon request for institutions and surgeons seeking added transparency or approval for procurement. These certifications reflect Desu’s ongoing commitment to quality, innovation, and patient safety.

Biologically Intelligent Engineering

The use of high-purity collagen in DECOLL ensures not only compatibility with human tissue but also promotes biological resorption and remodeling. Once implanted, DECOLL serves as a scaffold for native tissue growth, gradually integrating into the patient’s body and being absorbed over time. This eliminates the need for later removal or revision, significantly reducing patient risk and hospital resources.

Its impermeable pore structure makes DECOLL highly effective in preventing cerebrospinal fluid (CSF) leakage, a major concern in post-neurosurgical outcomes. Unlike synthetic or lower-quality materials, DECOLL forms a tight seal that supports both healing and fluid control—minimizing postoperative complications and improving recovery.

Key Features and Clinical Benefits

DECOLL is tailored to the needs of modern neurosurgical teams through the following advantages:

Biodegradable and Resorbable: Gradually absorbed and replaced by the patient’s own connective tissue.

CSF Leak Protection: Impermeable structure acts as an effective fluid barrier.

High Tensile Strength: Resistant to tearing during suturing or manipulation.

Dual-Surface Usability: Both sides of the membrane can be placed against tissue.

Ready-to-Use: No need for rehydration or chemical preparation.

Gamma Sterilized: Ensures complete sterility without altering collagen quality.

These features make DECOLL suitable for a wide range of neurosurgical applications and help streamline workflow in both emergency and elective procedures.

Broad Surgical Applications

DECOLL is indicated for use in both cranial and spinal procedures, particularly where the dura has been compromised due to:

Spinal and cranial tumor resection

Decompressive laminectomy

Chiari malformation surgery

Myelomeningocele repair

CSF leak management

Traumatic dural injuries

Congenital dural defects

Post-operative reinforcement

Its ability to adapt to irregular anatomical surfaces, combined with its soft yet strong consistency, ensures optimal conformability and secure placement across various surgical fields.

Handling and Surgeon Experience

DECOLL offers an excellent balance between structural strength and pliability. Surgeons can trim the membrane to size with surgical scissors, position it with forceps, and either suture it in place or use it as an onlay—depending on preference and clinical requirements.

It resists curling, fragmentation, or shrinkage during handling and maintains its properties under surgical conditions, including exposure to blood, irrigation, and instruments. Both its visual clarity and tactile responsiveness support precise application under microscope or loupes.

Standard Sizes and Ordering Options

To accommodate a variety of dural defect sizes, DECOLL is offered in several square formats. This helps minimize waste and gives surgeons the flexibility to select the appropriate size for each individual case.

Each sheet is individually sterile-packaged and labeled for surgical use, with full lot traceability and expiration date markings.

Clinical Assurance and Biocompatibility

DECOLL has undergone rigorous biocompatibility testing according to ISO 10993 standards, including cytotoxicity, sensitization, systemic toxicity, and implantation response. All testing confirms DECOLL’s safety for human implantation and its compatibility with critical neuroanatomical tissues.

In addition, its collagen matrix has been evaluated for mechanical durability, absorption behavior, and tissue integration, demonstrating strong performance across all critical metrics for neurosurgical graft materials.

Why DECOLL?

When selecting a dura substitute, neurosurgeons prioritize reliability, safety, and tissue compatibility. DECOLL answers each of these needs with a scientifically advanced design, proven clinical performance, and a handling profile that supports surgical precision.

With its CE and ISO certifications, DECOLL also provides purchasing teams and hospital administrators with assurance of regulatory compliance, proven quality, and global clinical usability.

Whether you are repairing trauma-induced defects, reinforcing closure after tumor removal, or preventing CSF leaks in high-risk patients, DECOLL delivers what surgeons and patients both need: strength, integration, and safety.

Contact Desu for More Information

To learn more about DECOLL, request CE documentation, or receive surgical samples for evaluation, contact the Desu Medical team. Our dedicated team of specialists is ready to provide technical support, purchasing assistance, and product education tailored to your needs.