COLL-OS Collagen Based Grafts
The dura mater is a critical protective membrane surrounding the brain and spinal cord. When this structure is compromised due to trauma, surgical intervention, or disease, a durable, biocompatible, and regenerative substitute is essential for successful healing and complication prevention. In response to these clinical demands, Desu Medical introduces COLL-OS — an advanced, collagen-based dural graft engineered for safety, integration, and performance in a wide range of neurosurgical applications.
COLL-OS is crafted from ultra-pure type I bovine collagen, with a purity level greater than 95.5%. It serves as a biological dural substitute, offering both mechanical protection and a bioactive scaffold that supports natural tissue regeneration. Designed for ease of use and optimal surgical outcomes, COLL-OS represents a dependable solution for repairing dura mater defects and restoring neuroanatomical integrity.
Biomimetic Composition and Biological Integration
COLL-OS is formulated from highly purified type I collagen, the main structural protein in human connective tissue and dura mater. Its naturally derived matrix allows for excellent biocompatibility, low immunogenicity, and seamless integration with surrounding tissue. Once implanted, COLL-OS acts as a biological scaffold, supporting the migration and proliferation of fibroblasts and other healing cells.
The matrix is biodegradable, gradually resorbing into the body over time and being replaced by endogenous connective tissue. This eliminates the need for removal or revision procedures and supports physiological healing pathways.
Superior Barrier Function and CSF Leak Protection
One of the most significant postoperative risks in neurosurgical procedures is cerebrospinal fluid (CSF) leakage. COLL-OS is engineered with a tight, impermeable pore structure, which provides an exceptional fluid seal compared to conventional materials. This barrier functionality reduces the risk of infections such as meningitis, shortens hospitalization, and improves recovery outcomes.
Whether used in high-pressure CSF environments or as reinforcement over sutured dura, COLL-OS delivers fluid-tight sealing, maintaining surgical site integrity and patient safety.
Sterile, Ready-to-Use, and Time-Saving
COLL-OS is gamma-sterilized to eliminate microbial contamination and is packaged in double-blister sterile containers to maintain aseptic conditions until application. Unlike some alternatives, COLL-OS requires no pre-treatment or hydration before use — it is ready to use straight from the package.
This convenience allows surgeons to focus on the procedure without delays, particularly in urgent or trauma-related cases, where time efficiency is critical.
COLL-OS is suitable for both cranial and spinal procedures and offers versatile usage modes:
Onlay application: The graft is laid over the dura defect and can be held in place with fibrin sealant or surgical glue.
Suturable if required: COLL-OS possesses sufficient tensile strength for gentle suturing in more complex reconstructions.
Wide anatomical adaptation: Its flexibility and conformability allow use in deep, irregular, or curved surgical sites.
Surgeons may also use COLL-OS in combination with autologous tissue, synthetic patches, or absorbable sealants, depending on the requirements of the case.
Key Benefits of COLL-OS
>95.5% Type I Collagen: Ensures biocompatibility, structural integrity, and healing compatibility.
Bioabsorbable and Biocompatible: Supports regeneration and eliminates long-term foreign material presence.
Effective Barrier to CSF: Prevents post-op CSF leakage due to low porosity and dense fibrillar structure.
No Pre-Wetting Required: Reduces preparation time and improves workflow efficiency.
Flexible, Strong, and Easy to Handle: Maintains structure during placement and manipulation.
Sterile and Safe: Gamma sterilized with validated sterility assurance.
Ready-to-Use: Simplifies surgical handling, minimizes OR time.
Suitable for a Range of Indications: Compatible with cranial, spinal, and reconstructive neurosurgical applications.
Common Surgical Indications
COLL-OS is applicable in a wide variety of neurosurgical and spinal procedures, including:
Repair of dural defects after craniotomy or laminectomy
Reinforcement after tumor resection (spinal or cranial)
Spinal decompression surgeries
Myelomeningocele or lipoma correction
Trauma-induced dura injuries
CSF fistula and leak closure
Chiari malformation decompression
Congenital dural abnormality correction
Its broad clinical utility allows neurosurgeons, spine surgeons, and pediatric specialists to incorporate COLL-OS into their standard grafting protocol with confidence.
Available Sizes and Reference Codes
To meet the needs of varied surgical settings, COLL-OS is available in multiple standardized dimensions, making selection easy and reducing waste in the operating room.
Reference Code | Product Description |
CLS1525 | Collagen-Based Dural Graft 1.25 x 2.5 cm |
CLS152 | Collagen-Based Dural Graft 1.5 x 2 cm |
CLS23 | Collagen-Based Dural Graft 2 x 3 cm |
CLS2525 | Collagen-Based Dural Graft 2.5 x 2.5 cm |
All units are packaged in double-sterile blister pouches, clearly labeled with lot numbers and expiration dates for hospital inventory and regulatory compliance.
CE and ISO Certified Quality
COLL-OS is CE-marked in accordance with European Medical Device Regulations, confirming its compliance with health, safety, and environmental requirements. It is also manufactured under ISO certified processes, ensuring the highest standards of quality assurance and traceability.
These certifications make COLL-OS a trustworthy choice for hospitals, surgical centers, and international distributors seeking a product that aligns with global regulatory frameworks and clinical expectations.
Biocompatibility and Performance Testing
All COLL-OS units are tested according to ISO 10993 biocompatibility standards, including:
Cytotoxicity
Sensitization and irritation
Systemic toxicity
Genotoxicity
Implantation safety
In addition to biological testing, Desu Medical subjects COLL-OS to mechanical strength analysis, sterility validation, and shelf-life stability studies, ensuring consistent quality and reliability in the operating room.
Why Choose COLL-OS?
COLL-OS stands at the intersection of clinical performance and ease of use. It offers neurosurgeons a trusted dural substitute that is biologically safe, easily handled, and backed by rigorous testing and certification. Whether in a complex brain surgery or routine spinal closure, COLL-OS adapts to surgical needs and enhances patient outcomes.
Backed by Desu’s legacy of innovation and a commitment to clinical excellence, COLL-OS delivers on every front: protection, performance, and peace of mind.
To learn more about COLL-OS, request a sample, or speak with a Desu product specialist, please contact us:
🌐 Website: www.desu.tr/contact
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