DURASHEET Collagen Dura Membrane
Collagen-Based Dura Membrane for Neurosurgical Repair
In complex neurosurgical procedures, the integrity of the dura mater—the tough outermost membrane surrounding the brain and spinal cord—is often compromised. Whether due to trauma, tumor resection, congenital malformations, or spinal decompression surgeries, the restoration of dural continuity is critical to preventing cerebrospinal fluid (CSF) leakage, infection, and other serious complications. To address this need with precision and biological compatibility, Desu proudly presents DURASHEET™, an advanced collagen dura membrane engineered for high-performance dural repair and regeneration.
DURASHEET™ is a single-use, collagen-based implant made from ultra-pure, medical-grade type-1 bovine collagen, boasting a purity level of more than 95.5%. It serves as a biological substitute for the dura mater, delivering a natural and highly biocompatible scaffold that supports tissue integration, sealing, and healing in both cranial and spinal neurosurgical applications.
Engineered for Clinical Excellence
One of the key differentiators of DURASHEET™ is its collagen composition. Type-1 collagen is the principal structural protein found in native dura, and its use in this product ensures biological familiarity, reduced immunogenicity, and optimal healing kinetics. Once implanted, the membrane gradually biodegrades, leaving behind a new layer of healthy, patient-derived connective tissue. This natural resorption process minimizes foreign body response and avoids the long-term complications associated with synthetic dural substitutes.
Thanks to its impermeable pore structure, DURASHEET™ provides exceptional fluid barrier properties, which significantly reduce the risk of CSF leakage. Unlike some competitive materials, it does not allow microfiltration through the membrane, thereby enhancing postoperative protection and promoting a dry surgical field.
Furthermore, DURASHEET™ does not require any pre-processing before implantation. The product is ready to use out of the package and can be quickly cut to size, shaped, and positioned according to the anatomical and surgical needs. This makes it an ideal choice in both elective and emergency procedures, where time efficiency and reliability are paramount.
Key Clinical Benefits
DURASHEET™ is designed with a suite of features that elevate its performance across a wide range of neurosurgical interventions:
More Suturable: The collagen membrane is engineered to withstand suturing, making it an excellent choice for secure mechanical fixation to surrounding dura or fascia.
Superior Tensile Strength: DURASHEET™ is reinforced with high tensile strength properties, offering resistance to tearing or rupture during manipulation and placement.
Dual-Surface Usability: Both sides of the membrane are usable, reducing orientation errors and simplifying application, particularly in constrained operative fields.
High Absorption Capacity: The porous microstructure of the collagen allows for effective absorption of fluids, which aids in adhesion and healing.
These qualities make DURASHEET™ especially effective in high-pressure CSF environments and when used in conjunction with other neurosurgical closure materials such as fibrin glue, sealants, or tissue adhesives.
Versatile Applications Across Neurosurgery
DURASHEET™ is suitable for a variety of procedures that involve dural or spinal defects, including but not limited to:
Craniotomies with dural resection
Spinal tumor resections
Trauma-related dural breaches
Myelomeningocele and lipoma repair
Chiari malformation decompression
CSF fistula closures
Congenital spine defects
Because the membrane adapts well to the body’s natural contours and conforms easily to irregular surfaces, it can be used as both a primary dural substitute and as an overlay patch to reinforce existing closures.
Radiation Sterilized and Biologically Safe
Safety and sterility are at the core of Desu’s product development philosophy. DURASHEET™ is sterilized using Gamma irradiation, a method known for its deep-penetration and complete microbial elimination capabilities. This ensures that the product is free from endotoxins and pyrogens, making it suitable for use in sterile surgical environments without the need for additional washing, soaking, or conditioning.
The product is packaged in double-sterile pouches with clear labeling and reference coding for traceability and regulatory compliance. Each unit is single-use only and available in multiple sizes to accommodate various defect geometries.
Available Sizes for Tailored Solutions
DURASHEET™ is available in a range of square dimensions to provide surgeons with flexible options during intraoperative planning:
Reference Code | Product Description |
DRS2525 | DURASHEET™ Collagen Dura Membrane 2.5 x 2.5 cm |
DRS5050 | DURASHEET™ Collagen Dura Membrane 5 x 5 cm |
DRS7575 | DURASHEET™ Collagen Dura Membrane 7.5 x 7.5 cm |
DRS100100 | DURASHEET™ Collagen Dura Membrane 10 x 10 cm |
These size variations enable surgeons to select the most appropriate sheet for the anatomical region and extent of the defect, minimizing waste and reducing the need for intraoperative trimming.
Ideal Handling Characteristics
DURASHEET™ is easy to handle, suture, and secure. It maintains structural integrity when wet, remains flexible, and resists curling or fragmentation—common issues with many collagen-based materials. The sheet can be easily anchored with standard neurosurgical sutures or used as an onlay with biological adhesives.
Its white, non-transparent appearance allows for excellent visibility under the operating microscope, helping surgeons ensure precise placement and coverage. DURASHEET™ also supports stable manipulation with standard forceps and can be repositioned during application without structural compromise.
Biocompatibility and Performance Confirmed
Desu’s DURASHEET™ has been evaluated through rigorous biocompatibility testing, including assessments for cytotoxicity, sensitization, irritation, systemic toxicity, genotoxicity, and implant response. All results meet or exceed ISO 10993 standards for medical devices, providing clinicians and regulatory bodies with the assurance of safe long-term use in human applications.
The membrane has also been tested under various CSF pressure simulations, confirming its sealing performance and durability under physiological loads.
Supporting Rapid Healing
Thanks to its collagen-rich matrix and absorption profile, DURASHEET™ encourages angiogenesis, fibroblast infiltration, and the reformation of a natural dural layer. As the material gradually resorbs, it is replaced by native tissue, which restores both the anatomical barrier and physiological function of the dura mater. This healing synergy makes DURASHEET™ not only a barrier, but also a biological bridge to recovery.
DURASHEET™ by Desu is a next-generation collagen-based dura substitute that delivers superior sealing, biocompatibility, and handling performance. Whether used in cranial or spinal neurosurgery, DURASHEET™ provides a safe, sterile, and biologically integrative solution for dural repair—backed by Desu’s commitment to medical innovation and excellence.
If you’re looking to elevate the standard of care in your neurosurgical practice with a reliable, ready-to-use dural membrane, DURASHEET™ is the product of choice.
Contact Desu
To learn more about DURASHEET, request clinical data, or receive product samples for evaluation, please contact the Desu team today. Our product specialists are ready to assist you with all technical inquiries and ordering information.
🌐 Visit: www.desu.tr
📧 Email: [email protected]
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